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Targeted Allele Detail
Symbol: Tbc1d4tm1Lex
Name: TBC1 domain family, member 4; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3793866
Gene: Tbc1d4  Location: Chr14:101442360-101609191 bp, - strand  Genetic Position: Chr14, 50.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:135310
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the brown adipose tissue, white adipose tissue and soleus. (J:191749)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbc1d4 Mutation:  17 strains or lines available
Original:  J:135310 Chavez JA, et al., Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem. 2008 Apr 4;283(14):9187-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory