About   Help   FAQ
Tbc1d4tm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Tbc1d4tm1Lex
Name: TBC1 domain family, member 4; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3793866
Gene: Tbc1d4  Location: Chr14:101442360-101609191 bp, - strand  Genetic Position: Chr14, 50.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135310
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the brown adipose tissue, white adipose tissue and soleus. (J:191749)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbc1d4 Mutation:  27 strains or lines available
References
Original:  J:135310 Chavez JA, et al., Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem. 2008 Apr 4;283(14):9187-95
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory