Dmp1^tm2Mis
Targeted Allele Detail

Summary

• Symbol: Dmp1^tm2Mis
• Name: dentin matrix protein 1; targeted mutation 2, Yuji Mishina
• MGI ID: MGI:3793849
• Synonyms: Dmp1^fx
• Gene: Dmp1 Location: Chr5:104350479-104361968 bp, + strand Genetic Position: Chr5, 50.61 cM
• Alliance: Dmp1^tm2Mis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135314
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 6 and an additional loxP site was inserted upstream of exon 6. Germ line, flp-meditated recombination was used to remove the neo cassette leaving exon 6 floxed. (J:135314)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmp1 Mutation: 38 strains or lines available

References

• Original: J:135314 Feng JQ, et al., Generation of a conditional null allele for Dmp1 in mouse. Genesis. 2008 Feb;46(2):87-91
• All: 3 reference(s)