About   Help   FAQ
Targeted Allele Detail
Symbol: Pkd1tm2Som
Name: polycystin 1, transient receptor poteintial channel interacting; targetedmutation 2, Stefan Somlo
MGI ID: MGI:3793791
Synonyms: Pkd1flox
Gene: Pkd1  Location: Chr17:24549950-24596514 bp, + strand  Genetic Position: Chr17, 12.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:135301
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 4 and an additional loxP was inserted upstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette and leave exons 2 to 4 floxed. (J:135301)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:  99 strains or lines available
Original:  J:135301 Shibazaki S, et al., Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet. 2008 Jun 1;17(11):1505-16
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory