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Neu4tm1Avps
Targeted Allele Detail
Nomenclature
Symbol: Neu4tm1Avps
Name: sialidase 4; targeted mutation 1, Alexey V Pschezhetsky
MGI ID: MGI:3793789
Gene: Neu4  Location: Chr1:94020451-94028334 bp, + strand  Genetic Position: Chr1, 47.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135246
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 3 was replaced with a neo cassette. The absence of full-length transcript as confirmed by northern blot and RT-PCR analysis on brain extracts. (J:135246)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neu4 Mutation:  7 strains or lines available
References
Original:  J:135246 Seyrantepe V, et al., Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage. Hum Mol Genet. 2008 Jun 1;17(11):1556-68
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory