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Transgene Detail
Symbol: Tg(Myh6*)131Lnwd
Name: transgene insertion 131, Leslie Leinwand
MGI ID: MGI:3793714
Transgene: Tg(Myh6*)131Lnwd  Location: unknown  
Strain of Origin:  (CBA x C57BL/6)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Myh6*)131Lnwd expresses 1 gene
Mutation detailsA rat myosin heavy chain promoter drives the expression of a rat cardiac alpha myosin heavy chain (Myh6) cDNA that was modified by mutating residue 1445 from a G to an A, and the deletion of codons 468-527. This resulted in a R403G substitution and a deletion in the putative actin binding domain in the encoded protein. This transgenic line exhibits a mild phenotype. (J:36522)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:36522 Vikstrom KL, et al., Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy. Mol Med. 1996 Sep;2(5):556-67
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory