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Transgene Detail
Symbol: Tg(H2-Ea*deltaY)54Dim
Name: transgene insertion 54, Diane Mathis
MGI ID: MGI:3793482
Synonyms: Tg(dY301)3Strasbourg, Tg(dY301,54)3Strasbourg, WEdeltaY301, WEdeltaY301-54
Transgene: Tg(H2-Ea*deltaY)54Dim  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(H2-Ea*deltaY)54Dim expresses 1 gene
Mutation detailsA 9 kb fragment of the H2-Ea(k) from the A/J mouse (clone lambdaA/J p34.13) was modified at 3 positions creating the WE32 construct (modified H2-Ea). This was used as the basis for a mutant H2-Ea gene having a deletion of the Y box (from position -61 to position -48). The resulting 8 kb transgenic construct WEdeltaY301 was injected into (C57BL/6 x SJL)F2 embryo pronuclei. Multiple lines - 22, 45, 54, 58, and 59, were derived, and 54 was donated to The Jackson Laboratory. S1 nuclease mapping shows that little H2-Ea mRNA is expressed in the spleen. Initiation of transcripts is aberrant. (J:135138)
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:135138 Dorn A, et al., Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6249-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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