Gt(ROSA)26Sor^{tm2(icre/ERT2)Jphe}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(icre/ERT2)Jphe}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jean-Paul Herman
• MGI ID: MGI:3793441
• Synonyms: Cre2ERT2, ERT2-iCre-ERT2, Gt(ROSA)26Sor^{tm2(cre/ESR1)Jphe}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(icre/ERT2)Jphe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135150
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(icre/ERT2)Jphe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: A humanized cre gene flanked by 2 tamoxifen-binding domains (ERT2-icre-ERT2) and followed by an frt-flanked hygro cassette was knocked into the locus. Inducible cre expression is present in all cells following treatment with tamoxifen with only the brain exhibiting decresed expression levels. (J:135150)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities Alliance mouse Gt(ROSA)26Sor gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:135150 Jullien N, et al., Use of ERT2-iCre-ERT2 for conditional transgenesis. Genesis. 2008 Apr;46(4):193-9
• All: 1 reference(s)