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Gata4tm1.2Sad
Targeted Allele Detail
Nomenclature
Symbol: Gata4tm1.2Sad
Name: GATA binding protein 4; targeted mutation 1.2, Stephen A Duncan
MGI ID: MGI:3793424
Gene: Gata4  Location: Chr14:63198922-63271692 bp, - strand  Genetic Position: Chr14, 33.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135185
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Exons 4 and 5 were deleted by cre mediated recombination in ES cells. (J:135185)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:  23 strains or lines available
References
Original:  J:135185 Zhao R, et al., Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol. 2008 May 15;317(2):614-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory