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Gria1tm5Rlh
Targeted Allele Detail
Nomenclature
Symbol: Gria1tm5Rlh
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 5, Richard L Huganir
MGI ID: MGI:3793349
Synonyms: Gria1Ser 831
Gene: Gria1  Location: Chr11:57011571-57330244 bp, + strand  Genetic Position: Chr11, 34.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135196
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
 
Mutation detailsExon 17 was replaced with one in which a nucleotide substitution resulted in an amio acid substitution of alanine for serine at position 831 (S831A). A neo cassette used as a selectable marker was removed by germline, cre-mediated recombination. (J:135196)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria1 Mutation:  11 strains or lines available
References
Original:  J:135196 Crombag HS, et al., A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning. Behav Brain Res. 2008 Aug 22;191(2):178-83
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory