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Targeted Allele Detail
Symbol: Gp1bbtm2Frla
Name: glycoprotein Ib, beta polypeptide; targeted mutation 2, Francois Lanza
MGI ID: MGI:3793297
Synonyms: GPIbbetadeltaIC
Gene: Gp1bb  Location: Chr16:18620319-18622403 bp, - strand  Genetic Position: Chr16, 11.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:135065
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Humanized sequence, Hypomorph, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted upstream of the coding region and the coding region was replaced with one in which the intracellular domain has been deleted. Cre mediated recombination was used to remove the neo cassette. (J:135065)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gp1bb Mutation:  2 strains or lines available
Original:  J:135065 Strassel C, et al., Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome. Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):241-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory