Bub1^tm1Jvd
Targeted Allele Detail

Summary

• Symbol: Bub1^tm1Jvd
• Name: BUB1, mitotic checkpoint serine/threonine kinase; targeted mutation 1, Jan M A van Deursen
• MGI ID: MGI:3793291
• Synonyms: Bub1^N
• Gene: Bub1 Location: Chr2:127643036-127673785 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Bub1^tm1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135093
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A neo cassette with a 3' loxP site was inserted upstream of exon 9 and an additional loxP site was inserted downstream of exon 9. This allele is hypomorphic because of a cryptic exon located within the neo gene that is known to reduce the level of normally spliced mRNA. (J:135093)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1 Mutation: 52 strains or lines available

References

• Original: J:135093 Jeganathan K, et al., Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol. 2007 Oct 22;179(2):255-67
• All: 1 reference(s)