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Egln1tm1.1Kael
Targeted Allele Detail
Nomenclature
Symbol: Egln1tm1.1Kael
Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1.1, William G Kaelin
MGI ID: MGI:3793288
Synonyms: PHD2-
Gene: Egln1  Location: Chr8:124908587-124949324 bp, - strand  Genetic Position: Chr8, 72.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132718
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed exon 2 and 3 of Egln1tm1Kael were removed via cre-mediated recombination by mating with Tg(EIIa-cre)C5379Lmgd mice. Egln1 mRNA and protein are undetectable in MEFs isolated from E12.5 embryos. (J:132718)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egln1 Mutation:  11 strains or lines available
References
Original:  J:132718 Minamishima YA, et al., Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood. 2008 Mar 15;111(6):3236-44
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory