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Targeted Allele Detail
Symbol: Ror2tm1Anec
Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, Aris N Economides
MGI ID: MGI:3793279
Synonyms: Ror2W749FLAG, Ror2W749X
Gene: Ror2  Location: Chr13:53109312-53286124 bp, - strand  Genetic Position: Chr13, 27.68 cM, cytoband B3
Germline Transmission:  Earliest citation of germline transmission: J:134490
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe region encoding W749 to D930 was replaced with a fused, in-frame FLAG-encoding sequence followed by a neo cassette. RT-PCR confirmed the absence of wild-type transcript and the presence of the tagged truncated product in E15.5 embryos. (J:134490)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ror2 Mutation:  92 strains or lines available
Original:  J:134490 Raz R, et al., The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development. 2008 May;135(9):1713-23
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory