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Klrk1tm1Dhr
Targeted Allele Detail
Nomenclature
Symbol: Klrk1tm1Dhr
Name: killer cell lectin-like receptor subfamily K, member 1; targeted mutation 1, David H Raulet
MGI ID: MGI:3790957
Synonyms: NKG2D-
Gene: Klrk1  Location: Chr6:129610323-129623864 bp, - strand  Genetic Position: Chr6, 63.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134509
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1b through exon 6 were replaced by a floxed neomycin resistance cassette through homologous recombination. Mice carrying germline mutations were crossed with a cre transgenic mouse strain to remove the neomycin selection cassette, leaving a single loxP site behind. Gene inactivation was confirmed by a lack of protein staining on NK cells using flow cytometry. (J:134509)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Klrk1 Mutation:  15 strains or lines available
References
Original:  J:134509 Guerra N, et al., NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity. 2008 Apr;28(4):571-80
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory