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Ezh2tm1Sho
Targeted Allele Detail
Summary
Symbol: Ezh2tm1Sho
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 1, Stuart Orkin
MGI ID: MGI:3790775
Synonyms: Ezh2F
Gene: Ezh2  Location: Chr6:47507073-47572275 bp, - strand  Genetic Position: Chr6, 22.92 cM, cytoband B
Alliance: Ezh2tm1Sho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134477
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP was inserted upstream of exon 16 and another downstream of exon 17. These exons contain part of the catalytic SET domain. (J:134477)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ezh2 Mutation:  72 strains or lines available
References
Original:  J:134477 Puschendorf M, et al., PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet. 2008 Apr;40(4):411-20
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory