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Cdsntm1Mmat
Targeted Allele Detail
Nomenclature
Symbol: Cdsntm1Mmat
Name: corneodesmosin; targeted mutation 1, Mitsuru Matsumoto
MGI ID: MGI:3790339
Gene: Cdsn  Location: Chr17:35552128-35557180 bp, + strand  Genetic Position: Chr17, 18.7 cM
Cdsntm1Mmat/Cdsntm1Mmat mice exhibit stratum corneum detachment due to defective desmosome formation

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134613
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 1 and all of exon 2 were replaced with a LacZ-neo fusion gene via homologous recombination. Western blot analysis confirmed the absence of protein in homozygous skin. (J:134613)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdsn Mutation:  16 strains or lines available
References
Original:  J:134613 Matsumoto M, et al., Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6720-4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory