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Upf2tm1.1Btp
Targeted Allele Detail
Nomenclature
Symbol: Upf2tm1.1Btp
Name: UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1.1, Bo Torben Porse
MGI ID: MGI:3790199
Synonyms: Upf2delta
Gene: Upf2  Location: Chr2:5951469-6056703 bp, + strand  Genetic Position: Chr2, 3.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134765
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 2 (containing the start methionine codon) and 3 were removed by germ line, cre mediated recombination. This allele is expected to produce a functionally inactive protein lacking several important domains including the N-terminal domain required for Upf1 interaction and nonsense-mediated mRNA decay (NMD). (J:134765)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Upf2 Mutation:  34 strains or lines available
References
Original:  J:134765 Weischenfeldt J, et al., NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev. 2008 May 15;22(10):1381-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory