Gpr85^tm1Mima
Targeted Allele Detail

Summary

• Symbol: Gpr85^tm1Mima
• Name: G protein-coupled receptor 85; targeted mutation 1, Mitsuyuki Matsumoto
• MGI ID: MGI:3789983
• Synonyms: SREB2 KO
• Gene: Gpr85 Location: Chr6:13834457-13839941 bp, - strand Genetic Position: Chr6, 5.76 cM
• Alliance: Gpr85^tm1Mima page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134303
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted between exon 3 and 4. The absence of transcript expression was confirmed by quantitative RT-PCR on brain extracts. (J:134303)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr85 Mutation: 17 strains or lines available

References

• Original: J:134303 Matsumoto M, et al., The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6133-8
• All: 2 reference(s)