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Gpr85tm1Mima
Targeted Allele Detail
Nomenclature
Symbol: Gpr85tm1Mima
Name: G protein-coupled receptor 85; targeted mutation 1, Mitsuyuki Matsumoto
MGI ID: MGI:3789983
Synonyms: SREB2 KO
Gene: Gpr85  Location: Chr6:13834458-13839942 bp, - strand  Genetic Position: Chr6, 5.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134303
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neo cassette was inserted between exon 3 and 4. The absence of transcript expression was confirmed by quantitative RT-PCR on brain extracts. (J:134303)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpr85 Mutation:  3 strains or lines available
References
Original:  J:134303 Matsumoto M, et al., The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6133-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory