Tg(Pim1-Eg5)1Jus
Transgene Detail

Summary

• Symbol: Tg(Pim1-Eg5)1Jus
• Name: transgene insertion 1, Monica Justice
• MGI ID: MGI:3789934
• Synonyms: Eg5-1, Pim1-Eg5
• Transgene: Tg(Pim1-Eg5)1Jus Location: unknown
• Alliance: Tg(Pim1-Eg5)1Jus page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pim1-Eg5)1Jus expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kif11 (MGI:1098231)

• Mutation details: Transgenic mice express mouse Eg5 under the control of a Pim1 promoter and Emu enhancer. Lung and liver tissues show a 60-fold overexpression level and brain and kidney show a 15-fold overexpression. Many other tissues display 4-fold overexpression. (J:127104)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pim1-Eg5)1Jus

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127104 Castillo A, et al., Overexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Res. 2007 Nov 1;67(21):10138-47
• All: 2 reference(s)