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Tg(Pfkl)224Yg
Transgene Detail
Nomenclature
Symbol: Tg(Pfkl)224Yg
Name: transgene insertion 224, Yorum Groner
MGI ID: MGI:3789607
Synonyms: PFKL mini-gene
Transgene: Tg(Pfkl)224Yg  Location: unknown  
Transgene
origin
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pfkl)224Yg expresses 1 gene
 
Mutation detailsThe transgenic construct for Tg(Pfkl)224Yg has 2.9 kb of the 5' genomic region, the first exon, first intron, and some of the second intron of Pfkl followed by the cDNA sequence extending to the 3' untranslated sequence and then genomic sequence from the 3' untranslated region was place downstream of this. A 22 base pair deletion was introduced into this 3' untranslated sequence in order to provide a system for detection of transgene-derived transcript. Line 224 was found to have several dozen copies of the transgene. (J:18425)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:18425 Elson A, et al., Overexpression of liver-type phosphofructokinase (PFKL) in transgenic-PFKL mice: implication for gene dosage in trisomy 21. Biochem J. 1994 Apr 15;299(Pt 2):409-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory