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Transgene Detail
Symbol: Tg(Ckm-LPL)1Rze
Name: transgene insertion 1, Rudolf Zechner
MGI ID: MGI:3789040
Transgene: Tg(Ckm-LPL)1Rze  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Ckm-LPL)1Rze expresses 1 gene
Mutation detailsMouse Ckm promoter was used to drive skeletal and cardiac muscle-specific expression of human LPL with a G to A transition at position 721 that results in an amino acid substitution of aspartic acid to asparagine at position 156 (D156N). This mutation results in an enzymatically inactive protein. Two lines were created (lines 1 and 2). (J:134517)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:134517 Merkel M, et al., Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13841-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory