Gt(ROSA)26Sor^{tm1(Tgfbr1*)Crm}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Tgfbr1*)Crm}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Benoit de Crombrugghe
• MGI ID: MGI:3785744
• Synonyms: TBR1^CA
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Tgfbr1*)Crm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134135
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Tgfbr1*)Crm} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tgfbr1 (MGI:98728)

• Mutation details: A floxed neo-STOP cassette followed by a cDNA encoding a constitutively active hemagglutinin-tagged Tgfbr1 was inserted into the locus. Expression of Tfgbr1 can only be detected upon cre-mediated removal of the neo-STOP cassette. (J:134135)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:134135 Sonnylal S, et al., Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum. 2007 Jan;56(1):334-44
• All: 4 reference(s)