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Gt(ROSA)26Sortm1(Tgfbr1*)Crm
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(Tgfbr1*)Crm
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Benoit de Crombrugghe
MGI ID: MGI:3785744
Synonyms: TBR1CA
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134135
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Tgfbr1*)Crm expresses 1 gene
 
Mutation detailsA floxed neo-STOP cassette followed by a cDNA encoding a constitutively active hemagglutinin-tagged Tgfbr1 was inserted into the locus. Expression of Tfgbr1 can only be detected upon cre-mediated removal of the neo-STOP cassette. (J:134135)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  434 strains or lines available
References
Original:  J:134135 Sonnylal S, et al., Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum. 2007 Jan;56(1):334-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory