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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(Tgfbr1*)Crm
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Benoit de Crombrugghe
MGI ID: MGI:3785744
Synonyms: TBR1CA
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:134135
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm1(Tgfbr1*)Crm expresses 1 gene
Mutation detailsA floxed neo-STOP cassette followed by a cDNA encoding a constitutively active hemagglutinin-tagged Tgfbr1 was inserted into the locus. Expression of Tfgbr1 can only be detected upon cre-mediated removal of the neo-STOP cassette. (J:134135)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  408 strains or lines available
Original:  J:134135 Sonnylal S, et al., Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum. 2007 Jan;56(1):334-44
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory