Hprt1^tm1(HP)Mae
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm1(HP)Mae
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Nobuyo Maeda
• MGI ID: MGI:3785623
• Synonyms: Hprt-Hp2
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm1(HP)Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134445
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^tm1(HP)Mae expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HP (3240)

  Hp	(MGI:96211)

• Mutation details: The human HP gene was knocked into the intron upstream of exon 3 along with a neo cassette repolacing the promoter and exons 1 and 2. Low levels of expression are detected in many tissues except for the small intestine. (J:134445)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:134445 Hatada S, et al., The influence of chromosomal location on the expression of two transgenes in mice. J Biol Chem. 1999 Jan 8;274(2):948-55
• All: 1 reference(s)