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Fermt3tm1Ref
Targeted Allele Detail
Nomenclature
Symbol: Fermt3tm1Ref
Name: fermitin family member 3; targeted mutation 1, Reinhard Fassler
MGI ID: MGI:3785479
Synonyms: Kind3-, Kindlin-3-
Gene: Fermt3  Location: Chr19:6976326-6996837 bp, - strand  Genetic Position: Chr19, 5.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133659
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 through 6 was replaced with an IRES/lacZ/neo cassette. The absence of protein product was confirmed by western blot analysis on spleen and platelet extracts. This is a reporter and null allele. (J:133659)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fermt3 Mutation:  18 strains or lines available
References
Original:  J:133659 Moser M, et al., Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med. 2008 Mar;14(3):325-30
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory