About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Transgene Detail
Symbol: Tg(Thy1-SOD1*G93A)T1Hgrd
Name: transgene insertion T1, Casper Hoogenraad
MGI ID: MGI:3785266
Transgene: Tg(Thy1-SOD1*G93A)T1Hgrd  Location: unknown  
Strain of Origin:  FVB
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-SOD1*G93A)T1Hgrd expresses 1 gene
Mutation detailsThe transgene construct contains a modified regulatory region of the murine thy1.2 gene (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), upstream of a mutant human superoxide dismutase cDNA sequence (G93A-SOD1) harboring a single amino acid substitution of glycine to alanine at codon 93. Transgene expression throughout the brain adn spinal cord was determined by Western blot. Line T1 was used for further studies. (J:134095)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:134095 Jaarsma D, et al., Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J Neurosci. 2008 Feb 27;28(9):2075-88
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory