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Tg(Thy1-SOD1*G93A)T3Hgrd
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-SOD1*G93A)T3Hgrd
Name: transgene insertion T3, Casper Hoogenraad
MGI ID: MGI:3785090
Synonyms: Thy1.2-G93A
Transgene: Tg(Thy1-SOD1*G93A)T3Hgrd  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-SOD1*G93A)T3Hgrd expresses 1 gene
 
Mutation detailsThe transgene construct contains a modified regulatory region of the murine thy1.2 gene (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), upstream of a mutant human superoxide dismutase cDNA sequence (G93A-SOD1) harboring a single amino acid substitution of glycine to alanine at codon 93. Transgene expression throughout the brain adn spinal cord was determined by Western blot. Line T3 was characterized further. (J:134095)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:134095 Jaarsma D, et al., Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J Neurosci. 2008 Feb 27;28(9):2075-88
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory