About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Transgene Detail
Symbol: Tg(Thy1-SOD1*G93A)T3Hgrd
Name: transgene insertion T3, Casper Hoogenraad
MGI ID: MGI:3785090
Synonyms: Thy1.2-G93A
Transgene: Tg(Thy1-SOD1*G93A)T3Hgrd  Location: unknown  
Strain of Origin:  FVB
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-SOD1*G93A)T3Hgrd expresses 1 gene
Mutation detailsThe transgene construct contains a modified regulatory region of the murine thy1.2 gene (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), upstream of a mutant human superoxide dismutase cDNA sequence (G93A-SOD1) harboring a single amino acid substitution of glycine to alanine at codon 93. Transgene expression throughout the brain adn spinal cord was determined by Western blot. Line T3 was characterized further. (J:134095)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:134095 Jaarsma D, et al., Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J Neurosci. 2008 Feb 27;28(9):2075-88
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory