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FlnbGt(XD076)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: FlnbGt(XD076)Byg
Name: filamin, beta; gene trap XD076, BayGenomics
MGI ID: MGI:3784954
Gene: Flnb  Location: Chr14:7817957-7951588 bp, + strand  Genetic Position: Chr14, 4.59 cM
Mutation
origin
Mutant Cell Line:  XD076
Germline Transmission:  Earliest citation of germline transmission: J:134094
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Not Applicable)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsA gene trap insertion vector inserted into intron 20 of the gene. RT-PCR analysis showed that no detectable full length transcript was present in liver or kidney derived from homozygous mice. (J:134094)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flnb Mutation:  163 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:134094 Zheng L, et al., Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner. J Cell Biol. 2007 Jul 2;178(1):121-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory