Tg(HBVX)Gja
Transgene Detail

Summary

• Symbol: Tg(HBVX)Gja
• Name: transgene insertion, Gilbert Jay
• MGI ID: MGI:3784393
• Synonyms: HBx-Tg
• Transgene: Tg(HBVX)Gja Location: unknown
• Alliance: Tg(HBVX)Gja page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 1.15 kb fragment of HBV subtype adr DNA spanning nucleotides 707-1856 of the viral genome was cloned into CD-1 fertilized eggs. This DNA fragment contained the entire coding region of the HBx gene, transcriptional enshancer sequence, principal RNA start sites and a poly A site. Northern blot analysis confirmed transgene expression in the liver, kidney and testis. This allele was established in founder E1. In J:90881, this allele was further defined to carry only a single copy of the transgene, and that the restriction sites bordering the transgene had been destroyed. Incidence of hepatocellular neoplasia in heterozygote transgenic mice was similar to CD-1 background, while incidence in homozygous transgenic mice carrying 2 copies of the transgene was elevated. (J:78178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78178 Kim CM, et al., HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature. 1991 May 23;351(6324):317-20
• All: 2 reference(s)