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Erc2tm1.1Sud
Targeted Allele Detail
Nomenclature
Symbol: Erc2tm1.1Sud
Name: ELKS/RAB6-interacting/CAST family member 2; targeted mutation 1.1, Thomas C Sudhof
MGI ID: MGI:3783990
Synonyms: E2X, ELKS2alpha-
Gene: Erc2  Location: Chr14:27622428-28478537 bp, + strand  Genetic Position: Chr14, 16.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133656
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was used to place a loxP site in the 5' UTR of the gene in the AflII restriction site 70 bp 5' of the ATG. A tetracysteine tag was inserted in frame into the first coding exon (from GGLSGSS to GGLSGCCPGCCSGSS) and an frt-neo-frt-loxp cassette was inserted 110 bp downstream of exon 1 into the genomic NdeI site. The line was crossed to cre-transgenic mice to excise the first coding exon. Total brain protein levels are normal. Rims1 is 30% more soluble in a detergent-free fractionation. (J:133656)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Erc2 Mutation:  80 strains or lines available
References
Original:  J:133656 Sudhof TC, Generation of an Erc2 mutant allele. MGI Direct Data Submission. 2008;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory