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Rspo2tm1Hoka
Targeted Allele Detail
Summary
Symbol: Rspo2tm1Hoka
Name: R-spondin 2; targeted mutation 1, Hitoshi Okamoto
MGI ID: MGI:3783769
Gene: Rspo2  Location: Chr15:42884190-43034222 bp, - strand  Genetic Position: Chr15, 16.73 cM
Alliance: Rspo2tm1Hoka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133600
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame was replaced with a lacZ-neo cassette. The absence of transcript was confirmed by RT-PCR on E13.5 embryo extracts. This is a null allele as well as reporter allele with lacZ expression that recapitulates endogenous expression. (J:133600)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 49 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rspo2 Mutation:  19 strains or lines available
References
Original:  J:133600 Aoki M, et al., R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development. Dev Growth Differ. 2008 Feb;50(2):85-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory