Tpp2^tm1Gnie
Targeted Allele Detail

Summary

• Symbol: Tpp2^tm1Gnie
• Name: tripeptidyl peptidase II; targeted mutation 1, Gabriele Niedermann
• MGI ID: MGI:3783749
• Gene: Tpp2 Location: Chr1:43973130-44042160 bp, + strand Genetic Position: Chr1, 23.5 cM
• Alliance: Tpp2^tm1Gnie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133572
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 12 and an additional loxP site was inserted upstream of exon 11. Germ-line, flp-mediated recombination was used to remove the neo cassette leaving exons 11 and 12 floxed. (J:133572)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpp2 Mutation: 83 strains or lines available

References

• Original: J:133572 Huai J, et al., Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5177-82
• All: 1 reference(s)