About   Help   FAQ
Pbx1tm2Mlc
Targeted Allele Detail
Nomenclature
Symbol: Pbx1tm2Mlc
Name: pre B cell leukemia homeobox 1; targeted mutation 2, Micheal L Cleary
MGI ID: MGI:3783739
Gene: Pbx1  Location: Chr1:168119364-168432270 bp, - strand  Genetic Position: Chr1, 75.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132963
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsES cells containing one null Pbx1tm1Mlc allele were used in a second targeting event. The remaining wild-type allele was targeted by inserting a loxP site upstream of exon 3 and a loxP site and hygromycin-GFP fusion cassette downstream of exon 3. (J:132963)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx1 Mutation:  18 strains or lines available
References
Original:  J:132963 Sanyal M, et al., B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood. 2007 May 15;109(10):4191-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory