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Targeted Allele Detail
Symbol: Pbx1tm2Mlc
Name: pre B cell leukemia homeobox 1; targeted mutation 2, Micheal L Cleary
MGI ID: MGI:3783739
Gene: Pbx1  Location: Chr1:168119364-168432270 bp, - strand  Genetic Position: Chr1, 75.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:132963
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsES cells containing one null Pbx1tm1Mlc allele were used in a second targeting event. The remaining wild-type allele was targeted by inserting a loxP site upstream of exon 3 and a loxP site and hygromycin-GFP fusion cassette downstream of exon 3. (J:132963)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx1 Mutation:  18 strains or lines available
Original:  J:132963 Sanyal M, et al., B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood. 2007 May 15;109(10):4191-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory