Ace^tm7Keb
Targeted Allele Detail

Summary

• Symbol: Ace^tm7Keb
• Name: angiotensin I converting enzyme; targeted mutation 7, Kenneth E Bernstein
• MGI ID: MGI:3783350
• Synonyms: ACE.8
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm7Keb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92397
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: The neomycin resistance gene cassette followed by cardiac specific alpha-myosin heavy chain promoter was inserted between the endogenous somatic promoter and exon 1. ACE activity and protein expression was markedly increased in heart but virtually undetectable in kidney of homozygous mutant mice. (J:92397)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 54 strains or lines available

References

• Original: J:92397 Xiao HD, et al., Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. Am J Pathol. 2004 Sep;165(3):1019-32
• All: 5 reference(s)