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Acetm7Keb
Targeted Allele Detail
Nomenclature
Symbol: Acetm7Keb
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; targeted mutation 7, Kenneth E Bernstein
MGI ID: MGI:3783350
Synonyms: ACE.8
Gene: Ace  Location: Chr11:105858774-105880790 bp, + strand  Genetic Position: Chr11, 68.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92397
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Insertion
 
Mutation detailsThe neomycin resistance gene cassette followed by cardiac specific alpha-myosin heavy chain promoter was inserted between the endogenous somatic promoter and exon 1. ACE activity and protein expression was markedly increased in heart but virtually undetectable in kidney of homozygous mutant mice. (J:92397)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace Mutation:  36 strains or lines available
References
Original:  J:92397 Xiao HD, et al., Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. Am J Pathol. 2004 Sep;165(3):1019-32
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory