Tg(PRNP)650Insra
Transgene Detail

Summary

• Symbol: Tg(PRNP)650Insra
• Name: transgene insertion 650, Hubert Laude
• MGI ID: MGI:3783297
• Synonyms: tg650
• Transgene: Tg(PRNP)650Insra Location: unknown
• Alliance: Tg(PRNP)650Insra page

Transgene origin

• Strain of Origin: 129S7/SvEvBrd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PRNP)650Insra expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRNP (5621)

  Prnp	(MGI:97769)

• Mutation details: This transgene contains a human PAC with 110 kb long fragment with the entire human PRNP gene and flanking genes (such as DOPPLE). Three lines were created with 1, 3 and 5 copies of the PAC at one integration site. Line 650 contains 5 copies. Expression in the brain is 6-fold higher than in the null background. (J:131324)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This transgene was injected into 129S7/SvEvBrd cells containing Prnp^tm1Cwe.

References

• Original: J:131324 Beringue V, et al., Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD. PLoS One. 2008;3(1):e1419
• All: 7 reference(s)