Skap1^Gt713Lex
Gene trapped Allele Detail

Summary

• Symbol: Skap1^Gt713Lex
• Name: src family associated phosphoprotein 1; gene trap 713, Lexicon Genetics
• MGI ID: MGI:3783261
• Synonyms: SKAP-55^-
• Gene: Skap1 Location: Chr11:96355419-96649956 bp, + strand Genetic Position: Chr11, 59.93 cM
• Alliance: Skap1^Gt713Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126545
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The VICTR gene trap flanked by long terminal repeats was inserted into intron 4. The absence of protein product was confirmed by western blot analysis on T cell extracts. Authors state that this is a null allele because transcript expression is lost as confirmed by RT-PCR. (J:126545)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Skap1 Mutation: 51 strains or lines available

References

• Original: J:126545 Wang H, et al., Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol. 2007 Oct;27(19):6863-75
• All: 4 reference(s)