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Targeted Allele Detail
Symbol: Ltbp1tm1Rawe
Name: latent transforming growth factor beta binding protein 1; targeted mutation 1, Ralf Weiskirchen
MGI ID: MGI:3778910
Synonyms: Ltbp1DeltaEx5-
Gene: Ltbp1  Location: Chr17:75005568-75392512 bp, + strand  Genetic Position: Chr17, 46.24 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:133255
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ/neo cassette was inserted into exon 5. The absence of protein product was confirmed by western blot analysis on skin fibroblast extracts. This is a null allele that disrupts expression of both the long and short forms. (J:133255)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltbp1 Mutation:  7 strains or lines available
Original:  J:133255 Drews F, et al., Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability. Biochim Biophys Acta. 2008 Jan;1783(1):34-48
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory