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Transgenic Allele Detail
Symbol: Ifi208Tg(Cspg4-cre)1Akik
Name: interferon activated gene 208; transgene insertion 1, Akiko Nishiyama
MGI ID: MGI:3778062
Synonyms: Cspg4(NG2)-Cre, ng2-Cre, NG2creBAC, Tg(Cspg4-cre)1Akik
Gene: Ifi208  Location: Chr1:173673675-173698395 bp, + strand  Genetic Position: Chr1, 80.57 cM
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Mutation detailsThe transgene construct consisted of the 208 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-309G21, containing the entire NG2 (Cspg4) gene (and 60 kbp of 5' and 114 kbp of 3' flanking sequences), which was modified by inserting an nls-cre coding sequence followed by a rabbit beta-globin polyA signal into the first exon of the NG2 gene. The NG2 translation initiation ATG was changed to AAG to prevent translation from the BAC NG2 gene and to allow translation from the first ATG in the cre sequence. Cre expression is detected only in Cspg4-expressing cells at P1, P14 and P60 and not in Gfap +ve astrocytes or APC +ve oligodendrocytes. Activity is also detected in male germ cells. Line 1 inserted into an intron of the gene at 173692115 (Build GRCm38/mm10). Founder line 1 has a copy number of 1-3. (J:129201, J:185534)
 Tissue activity of this recombinase allele
Driver: Cspg4     Summary of all recombinase alleles driven by Cspg4. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ifi208 Mutation:  1 strain or line available
Original:  J:129201 Zhu X, et al., NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development. 2008 Jan;135(1):145-57
All:  50 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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