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Transgene Detail
Symbol: Tg(CD2-Mafk)1Staka
Name: transgene insertion 1, Satoru Takahashi
MGI ID: MGI:3777789
Synonyms: 194 (low copy), MafK transgenic line 194, VA-MafK/1 Tg
Transgene: Tg(CD2-Mafk)1Staka  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(CD2-Mafk)1Staka expresses 1 gene
Mutation detailsA full-length, 0.8-kb cDNA encoding the mouse MAFK protein with a N-terminal FLAG epitope was inserted into the VA CD2 expression vector between, 5', the promoter, ATG-free mutant first exon and first intron of the human CD2 gene and 3', also from the CD2 gene, ~500 bp of 3' untranslated and flanking DNA including two polyadenylation signals and the 3' locus control region. A lacZ reporter gene was shown to be expressed from this vector in mature peripheral CD4+CD8- and CD4-CD8+ SP T lymphocytes and in peripheral CD4-CD8- DN T cells. This line was estimated via densitometric analysis to carry 2 copies of the transgene. (J:105228, J:128658)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:128658 Yoh K, et al., Transgenic over-expression of MafK suppresses T cell proliferation and function in vivo. Genes Cells. 2001 Dec;6(12):1055-66
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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