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Rap1atm1Morz
Targeted Allele Detail
Nomenclature
Symbol: Rap1atm1Morz
Name: RAS-related protein 1a; targeted mutation 1, Alexei Morozov
MGI ID: MGI:3777591
Synonyms: Rap1Afloxed
Gene: Rap1a  Location: Chr3:105727267-105801336 bp, - strand  Genetic Position: Chr3, 46.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132855
Parent Cell Line:  MM13 (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 3. Transient expression of cre recombinase removed the neomycin cassette, leaving exons 2 and 3 flanked by loxP sites. Correct targeting was confirmed through Southern blots. (J:132855)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rap1a Mutation:  20 strains or lines available
References
Original:  J:132855 Pan BX, et al., Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci. 2008 Feb 27;28(9):2089-98
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory