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Egln1tm1Kael
Targeted Allele Detail
Nomenclature
Symbol: Egln1tm1Kael
Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1, William G Kaelin
MGI ID: MGI:3777476
Synonyms: Phd2F, PHD2 flox
Gene: Egln1  Location: Chr8:124908587-124949254 bp, - strand  Genetic Position: Chr8, 72.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132718
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 3. Germ-line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 and 3 floxed. (J:132718)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egln1 Mutation:  12 strains or lines available
References
Original:  J:132718 Minamishima YA, et al., Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood. 2008 Mar 15;111(6):3236-44
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory