Egln1^tm1Kael
Targeted Allele Detail

Summary

• Symbol: Egln1^tm1Kael
• Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1, William G Kaelin
• MGI ID: MGI:3777476
• Synonyms: Phd2^F, PHD2 flox
• Gene: Egln1 Location: Chr8:125635326-125676063 bp, - strand Genetic Position: Chr8, 72.86 cM
• Alliance: Egln1^tm1Kael page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132718
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 3. Germ-line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 and 3 floxed. (J:132718)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egln1 Mutation: 21 strains or lines available

References

• Original: J:132718 Minamishima YA, et al., Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood. 2008 Mar 15;111(6):3236-44
• All: 21 reference(s)