Tg(Hoxc11/lacZ)62D9Awg
Transgene Detail

Summary

• Symbol: Tg(Hoxc11/lacZ)62D9Awg
• Name: transgene insertion 62D9, Alexander Awgulewitsch
• MGI ID: MGI:3777105
• Synonyms: LZc11-S
• Transgene: Tg(Hoxc11/lacZ)62D9Awg Location: unknown
• Alliance: Tg(Hoxc11/lacZ)62D9Awg page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene was made from a 10-kb mouse genomic DNA fragment, derived from the CD-1 genomic cosmid clone cos2W3a, containing the Hoxc11 coding region with 2 kb of upstream and 5 kb of downstream flanking DNA. The E. coli lacZ coding sequence was inserted in-frame at an Eag1 restriction site in exon 1, replacing an internal Eag1 DNA fragment. Expression of beta-galactosidase from the transgene in 11.5-13.5 dpc embryos, detected by Xgal staining, recapitulates that of endogenous HOXC11 in the hindlimb and posterior proximal forelimb. (J:61447)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:61447 Papenbrock T, et al., Loss of fibula in mice overexpressing Hoxc11. Mech Dev. 2000 Apr;92(2):113-23
• All: 2 reference(s)