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Targeted Allele Detail
Symbol: Ovol2tm1Sito
Name: ovo like zinc finger 2; targeted mutation 1, Seiji Ito
MGI ID: MGI:3777011
Gene: Ovol2  Location: Chr2:144305175-144332146 bp, - strand  Genetic Position: Chr2, 70.99 cM, cytoband H1
Germline Transmission:  Earliest citation of germline transmission: J:132526
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3 and an additional loxP site was inserted upsream of exon 3. Transient cre expression in ES cells was used to remove the neo cassette and exon 3. The absence of endogenous transcript expression was confirmed by RT-PCR. (J:132526)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ovol2 Mutation:  18 strains or lines available
This allele was derived by cre mediated recombination from Ovol2tm2Sito
Original:  J:132526 Unezaki S, et al., Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice. Genes Cells. 2007 Jun;12(6):773-85
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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