About   Help   FAQ
Rtl1tm1Fuis
Targeted Allele Detail
Nomenclature
Symbol: Rtl1tm1Fuis
Name: retrotransposon-like 1; targeted mutation 1, Fumitoshi Ishino
MGI ID: MGI:3776873
Gene: Rtl1  Location: Chr12:109590169-109595403 bp, - strand  Genetic Position: Chr12, 60.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132647
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame was replaced with a neo cassette that was subsequently removed by transient cre expression. The absence of transcript expression was confirmed by RT-PCR. This allele also results in the deletion of 6 of the up to 7 microRNAs located within the anti-sense strand of the gene, which include: Mirn127, Mirn136, Mirn431, Mirn433 (5' and 3') and Mirn434 (5' and 3'). (J:132647)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rtl1 Mutation:  19 strains or lines available
References
Original:  J:132647 Sekita Y, et al., Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat Genet. 2008 Feb;40(2):243-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/18/2017
MGI 6.08
The Jackson Laboratory