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Rtl1tm1Fuis
Targeted Allele Detail
Nomenclature
Symbol: Rtl1tm1Fuis
Name: retrotransposon-like 1; targeted mutation 1, Fumitoshi Ishino
MGI ID: MGI:3776873
Gene: Rtl1  Location: Chr12:109590169-109595403 bp, - strand  Genetic Position: Chr12, 60.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132647
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame was replaced with a neo cassette that was subsequently removed by transient cre expression. The absence of transcript expression was confirmed by RT-PCR. This allele also results in the deletion of 6 of the up to 7 microRNAs located within the anti-sense strand of the gene, which include: Mirn127, Mirn136, Mirn431, Mirn433 (5' and 3') and Mirn434 (5' and 3'). (J:132647)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rtl1 Mutation:  18 strains or lines available
References
Original:  J:132647 Sekita Y, et al., Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat Genet. 2008 Feb;40(2):243-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory