Kng1^tm1Krmc
Targeted Allele Detail

Summary

• Symbol: Kng1^tm1Krmc
• Name: kininogen 1; targeted mutation 1, Keith R McCrae
• MGI ID: MGI:3776034
• Gene: Kng1 Location: Chr16:22876970-22900828 bp, + strand Genetic Position: Chr16, 13.88 cM, cytoband B1
• Alliance: Kng1^tm1Krmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130769
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10 was replaced with a floxed neo cassette. The absence of protein product was confirmed by western blot analysis on plasma. (J:130769)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kng1 Mutation: 45 strains or lines available

References

• Original: J:130769 Merkulov S, et al., Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. Blood. 2008 Feb 1;111(3):1274-81
• All: 5 reference(s)