Myh7^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Myh7^tm1Unc
• Name: myosin, heavy polypeptide 7, cardiac muscle, beta; targeted mutation 1, University of North Carolina
• MGI ID: MGI:3776012
• Synonyms: betaMHC-YFP, YFP-betaMHC
• Gene: Myh7 Location: Chr14:55208141-55232083 bp, - strand Genetic Position: Chr14, 28.01 cM
• Alliance: Myh7^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132484
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Coding seqeunce for YFP was knocked-in into beta MHC gene at the translational start site to produce an allele that expresses YFP fused to the native beta MHC protein. (J:132484)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myh7 Mutation: 96 strains or lines available

References

• Original: J:132484 Pandya K, et al., Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16864-9
• All: 4 reference(s)