Isx^tm1Sse
Targeted Allele Detail

Summary

• Symbol: Isx^tm1Sse
• Name: intestine specific homeobox; targeted mutation 1, Susumu Seino
• MGI ID: MGI:3775943
• Synonyms: Isx^LacZ
• Gene: Isx Location: Chr8:75599801-75620134 bp, + strand Genetic Position: Chr8, 35.54 cM, cytoband C2
• Alliance: Isx^tm1Sse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132176
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neo cassette was inserted into exon 1 replacing a portion of it. The neo cassette and the entire lacZ-neo cassette were flanked with recombination sites (exact kind not specified). The absence of transcript was confirmed by northern blot analysis on jejunum extracts. This is a null allele. (J:132176)

Expression

In Mice Carrying this Mutation:

32 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Isx Mutation: 22 strains or lines available

References

• Original: J:132176 Seino Y, et al., Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression. J Biol Chem. 2008 Feb 22;283(8):4905-11
• All: 1 reference(s)