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Targeted Allele Detail
Symbol: Ip6k1tm1.1Snyd
Name: inositol hexaphosphate kinase 1; targeted mutation 1.1, Solomon Snyder
MGI ID: MGI:3775918
Synonyms: IP6K1-
Gene: Ip6k1  Location: Chr9:108002501-108048782 bp, + strand  Genetic Position: Chr9, 59.07 cM, cytoband F2
Impaired spermiogenesis in Ip6k1tm1.1Snyd/Ip6k1tm1.1Snyd mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:132167
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe first part of exon 6 that contains the C-terminal coding region was removed by germ-line, cre-mediated recombination. The absence of transcript was confirmed by RT-PCR analysis on brain and liver extracts. (J:132167)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ip6k1 Mutation:  41 strains or lines available
Original:  J:132167 Bhandari R, et al., Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2349-53
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory