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Nlgn4lGt(XST093)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Nlgn4lGt(XST093)Byg
Name: neuroligin 4-like; gene trap XST093, BayGenomics
MGI ID: MGI:3775814
Synonyms: NL-4-KO, Nlgn3-, XST093Gt(pGT1TMpfs)1Ucd
Gene: Nlgn4l  Location: unknown  
Decrease of brain volume in Nlgn4lGt(XST093)Byg/Nlgn4lGt(XST093)Byg mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  XST093
Germline Transmission:  Earliest citation of germline transmission: J:131843
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT1TMpfs     Vector Type: secretory trap
 
Mutation detailsThe gene trap vector was inserted 340 bp downstream of the first exon. LacZ expression was confirmed by beta-galactosidase assay. The fusion protein produced by this allele is nonfuctional because it only possesses a small portion of the esterase domain and cannot bind neurexins. This is a null allele. (J:131843)
Sequence Tags: 
Sequence tag details (1 tag)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nlgn4l Mutation:  1 strain or line available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:131843 Jamain S, et al., Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1710-5
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory