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Targeted Allele Detail
Symbol: Cops5tm1Rpar
Name: COP9 signalosome subunit 5; targeted mutation 1, Ruggero Pardi
MGI ID: MGI:3775801
Synonyms: CSN5fl, CSN5/JAB1flox, Jab1fl
Gene: Cops5  Location: Chr1:10024601-10038168 bp, - strand  Genetic Position: Chr1, 2.29 cM
Germline Transmission:  Earliest citation of germline transmission: J:132114
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 and an additional loxP site was inserted upstream of exon 2. Germ-line, flp-mediated recombination was used to remove the neo cassette leaving a floxed exon 2. (J:132114)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cops5 Mutation:  8 strains or lines available
Original:  J:132114 Panattoni M, et al., Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development. J Exp Med. 2008 Feb 18;205(2):465-77
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory