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Rnf5tm1Zron
Targeted Allele Detail
Nomenclature
Symbol: Rnf5tm1Zron
Name: ring finger protein 5; targeted mutation 1, Ze'ev Ronai
MGI ID: MGI:3775796
Gene: Rnf5  Location: Chr17:34601091-34603690 bp, - strand  Genetic Position: Chr17, 18.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132185
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1, 2 and 3 were replaced with a neo cassette. This deletion spans the translation initiation site and the RING domain encoding exon. The absence of protein product was confirmed by western blot analysis on tibialis muscle extrtacts. (J:132185)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnf5 Mutation:  10 strains or lines available
References
Original:  J:132185 Delaunay A, et al., The ER-Bound RING Finger Protein 5 (RNF5/RMA1) Causes Degenerative Myopathy in Transgenic Mice and Is Deregulated in Inclusion Body Myositis. PLoS One. 2008;3(2):e1609
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory